Paeoniflorin 是一种 heat shock protein 诱导化合物
Paeoniflorin 是一种 heat shock protein 诱导化合物,普遍存在于芍药科植物中,具有多种生物活性,包括抗癌活性、抗炎活性、增强认知能力和减弱学习障碍、抗氧化应激、抗血小板聚集、扩张血管和降低血液粘度。
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CAS No. : 23180-57-6
Synonyms: 芍药苷; 芍药甙;Peoniflorin
体外研究
Paeoniflorin(80 μg/mL;4-24 小时)处理可诱导 Hsp40 和 Hsp27 以及 Hsp70[3]。
Paeoniflorin 相关抗体:Hsp70 1B Antibody (YA358)、Hsp70 Antibody (YA359)、HSC70 Antibody (YA360)、Hsp60 Antibody (YA729)
体内研究
Paeoniflorin(皮内注射;25 和 100 mg/kg;每天一次;20 天)对实验性关节炎显示出良好的效果[4]。
参考文献
[1]. Yan-Xi Zhou, et al. A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Biomed Pharmacother. 2020 Oct;130:110505.
[2]. Yongjing Xiang, et al. Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities. J Pharm Pharmacol. 2020 Apr;72(4):483-495.
[3]. Dai Yan, et al. Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones. 2004 Winter;9(4):378-89. Int J Oncol. 2013 Nov;43(5):1643-51.
[4]. Pei-Pei Li, et al. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012 May 7;141(1):290-300.

2025-09-10
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