硫酸葡聚糖钠盐(35000-45000)是一种脱水葡萄糖的聚
2025-07-16 
MCE
Dextran sulfate sodium salt (DSS) (MW 35000-45000) 是一种脱水葡萄糖的聚合物，分子量约为 35000-45000，不同分子量的 DSS 具有不同的生物活性。Dextran sulfate sodium salt (DSS) (MW 35000-45000) 是有效的结肠炎诱导剂。Dextran sulfate sodium salt (DSS) (MW 35000-45000) 可用于急性结肠炎，慢性结肠炎，结肠炎相关的结肠癌造模。Dextran sulfate sodium salt (DSS) (MW 35000-45000) 可能与巨噬细胞功能失调、肠道菌群失调有关，特别具有结肠上皮毒性。
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CAS No. : 9011-18-1
别名：硫酸葡聚糖钠盐 (35000-45000); DSS (MW 35000-45000); DXS (MW 35000-45000)；硫酸葡聚糖钠盐 (MW 35000-45000)
体内研究：
Dextran sulfate sodium salt (MW 35000-45000) 可用于诱导急性/慢性结肠炎和结肠炎相关的结肠癌模型[6][7][8][9][10]。
溶解性数据：
细胞实验：
H2O 中的溶解度 : ≥ 100 mg/mL
动物实验：
以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。
请依序添加每种溶剂： PBS
Solubility: 25 mg/mL; 澄清溶液; 超声助溶
参考文献
[1]. Lee KC, et al. Using Dextran-encapsulated gold nanoparticles as insulin carriers to prolong insulin activity. Nanomedicine (Lond). 2017 Aug;12(15):1823-1834.
[2]. Shen B, et al. Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-alcoholic Steatohepatitis. Front Microbiol. 2021 Nov 2;12:756299.
[3]. Li H, et al. Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation, regulating Th17/Treg balance, maintaining intestinal barrier integrity, and modulating gut microbiota. J Pharm Anal. 2022 Dec;12(6):824-838.
[4]. Whittem CG, et al. Murine Colitis modeling using Dextran Sulfate Sodium (DSS). J Vis Exp. 2010 Jan 19;(35):1652.
[5]. Martin JC, et al. Dextran Sulfate Sodium (DSS)-Induced Acute Colitis in the Rat. Methods Mol Biol. 2016;1371:197-203.
[6]. Kinchen J, et al. Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease. Cell. 2018 Oct 4;175(2):372-386.e17.
[7]. Zhang H, et al. Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice. Chem Biol Interact. 2024 May 25;395:111014.
[8]. Dokoshi T, et al. Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice. Nat Commun. 2024 Apr 8;15(1):3009.
[9]. Wirtz S, et al. Chemically induced mouse models of intestinal inflammation. Nat Protoc. 2007;2(3):541-6.
[10]. Zhu H, et al. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. J Exp Clin Cancer Res. 2017 Jan 5;36(1):2. [Content Brief]
